C2S-Scale converts a high-dimensional expression vector into text by rank-ordering genes and emitting the top-K symbols as a gene-name sequence. This representation aligns single-cell data with ...

Three draft recommendation documents published on Wednesday are intended to guide drug sponsors and accelerate the development of cell and gene therapies. The FDA has published three draft ...

This study presents the important finding that lysosomal damage triggers inflammatory signaling through ubiquitination and the TAB-TAK1-IKK-NF-kB axis. The data obtained from the unbiased ...

A study published in Global Medical Genetics by researchers at the Stephan Angeloff Institute of Microbiology has found that cannabidiol (CBD) produces wide-ranging genetic and molecular effects in ...

On Wednesday afternoon, Haifan Lin, the director of the Yale Stem Cell Center, discussed his innovative research findings in stem cell gene expression and regulation at Brown’s 2025 Mac V. Edds ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Loss of p300/CBP decreases the activity of ...

Translocations are chromosomal “cut and paste” errors that drive many lymphomas, a type of blood cancer and the sixth most common form of cancer overall. This includes mantle cell lymphoma, a rare but ...

Single cell gene expression studies often rely on single-cell RNA sequencing (scRNA-seq) alone. While scRNA-seq reveals which genes are turned on, it does not capture protein expression or changes to ...

Origin-recognition complex, or ORC, plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports. This is the first detailed study ...

Contributed by Peter C. Doherty; received January 16, 2025; accepted June 17, 2025; reviewed by Carole Guillonneau and Brian D. Rudd ...