The Canadian Journal of Statistics / La Revue Canadienne de Statistique, Vol. 24, No. 2 (Jun., 1996), pp. 177-192 (16 pages) Liang and Zeger (1986) introduced a class of estimating equations that ...

This is a preview. Log in through your library . Abstract We show in a general mixed model the best linear unbiased estimators (BLUE) of fixed effects, with unknown variance components substituted by ...

Genome-wide association studies (GWAS) are widely used to uncover novel genetic susceptibility loci for complex genetic diseases. If the true genetic model is known, the association test reflecting ...