A significant limitation to the analytical accuracy and precision of dual-labeled spotted cDNA microarrays is the signal error due to dye bias. Transcript-dependent ...

Gene therapy has often been described as a “black box” technique; that is, it is not known what happens to the cell after vector-mediated gene transfer. Although expression levels of the transgene are ...

Although prostate cancer initially responds and regresses in response to androgen-depletion therapy, most human prostate cancers will re-grow as an androgen-independent tumour. The goal of our study ...

Current microarray analysis uses 'chips' containing either 25-residue oligonucleotides synthesized by photolithography or cDNAs placed by robotic spotting. In the April Nature Biotechnology, Hughes et ...

Researchers at the National Institute on Aging will distribute a recently established mouse cDNA microarray/clone set containing 7,407 unique genes to 20 designated academic centers worldwide. The new ...

The Nottingham Prognostic Index (NPI) applied to 467 patients (pts) with a long-term follow-up that were treated in a single institution No significant financial relationships to disclose. This is an ...

Byung-IL Yoon, Guang-Xun Li, Kunio Kitada, Yasushi Kawasaki, Katsuhide Igarashi, Yukio Kodama, Tomoaki Inoue, Kazuko Kobayashi, Jun Kanno, Dae-Yong Kim, Tohru Inoue and Yoko Hirabayashi Although the ...

In each type of cell, like a muscle cell or a skin cell, different genes are expressed (turned on) or silenced (turned off). If the cells that are turned on mutate, they could—depending on what role ...

In this issue we take a close look at DNA microarrays, the current amore of biological and biomedical researchers. There's little reason to doubt that the infatuation will continue, at least for ...

No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2004 ASCO Annual Meeting. This abstract does not include a full text component.

Technology Set to Compete with Microarrays in This Application Arena Microarray-based gene-expression profiling technology hardly seems like it has been around long enough for a new approach to come ...