Regulatory mechanisms governing stem cell quiescence in glandular organs remain ill-defined. Here, multi-omics profiling ...
Breast cancer (BC) remains one of the most challenging cancers to treat, primarily due to its heterogeneity and propensity for metastasis. The Notch signaling pathway is integral to various cellular ...
Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...
Delta-like ligand-3 (DLL3) is a single-pass, type I transmembrane protein that inhibits the Notch signaling pathway. A highly conserved intercellular signaling pathway, the Notch signaling pathway ...
Chengjian Zhao, Jonathan Matalonga, Joseph J. Lancman, Lu Liu, Chaoxin Xiao, Shiv Kumar, Keith P. Gates, Jiaye He, Alyssa Graves, Jan Huisken, Mizuki Azuma, Zhenghao ...
The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...
Duoyan Rong, Shuai Zhao, Wenxin Tang, Nan Luo, Hai He, Zhuqing Wang, Huimin Ma, Yimei Huang, Xiaoxun Yao, Xue Pan, Lin Lv, Jiajing Xiao, Renyi Liu, Shingo Nagawa, Chizuko Yamamuro Proceedings of the ...
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