综上所述，这项研究描绘了一条精妙的肠道-大脑防御通路：在经历分解代谢挑战后的恢复期，摄入富含谷氨酰胺、赖氨酸和苏氨酸的蛋白质，会在肠道（尤其是十二指肠）产生大量氨；肠道嗜铬细胞通过其表面的TRPA1受体感知到这种氨负荷后，释放血清素；血清素信号继而通 ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

P-cadherin is a protein commonly found on malignant cancer cells and has been used as a target for antibody-based cancer treatments. UC Davis biomedical engineers have discovered that when an antibody ...

A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key ...

Researchers at Weill Cornell Medicine report that a rare gene mutation that delays Alzheimer’s disease does so by damping inflammatory signaling in brain-resident immune cells in a preclinical study.