Remodelling of RNA structures by proteins such as the DEAD-box (DDX) RNA helicases regulates gene expression at various stages. The budding yeast helicase Dhh1 and its human counterpart DDX6 are known ...

Identifying functional effects of noncoding variants is a major challenge in human genetics. To predict the noncoding-variant effects de novo from sequence, we ...

Premise of research. The transition from herbaceous annual to woody perennial has occurred numerous times during angiosperm evolution, but the suite of genetic changes that accompanies this life ...

Henry M. Kronenberg, Barbara E. McDevitt, Joseph A. Majzoub, Jeremy Nathans, Phillip A. Sharp, John T. Potts and Alexander Rich Proceedings of the National Academy of Sciences of the United States of ...

Superimposed on the genetic sequences coding for amino acids is a second genetic code. This second genetic code, which makes use of dual-use codons, or duons, specifies how genes are controlled. The ...

AMSTERDAM--(BUSINESS WIRE)--Annogen, the Amsterdam based biotech company behind the SuRE™ technology for the functional annotation of the non-coding part of the genome, today announced it has begun a ...

A DNA sequence code critical to our understanding of how human genes are turned on and off has just been unlocked by a team of scientists. Molecular biologists refer to this code as the “human ...

Actin cytoskeleton drives cell migration in muscle and non-muscle cells and plays a major role in such diverse processes as tissue morphogenesis, muscle contraction, and cancer metastases. In ...

Using STING-seq, short for systematic targeting and inhibition of noncoding GWAS loci with single cell sequencing, Sanjana and his team identified promising sequence variants linked to various ...

An online tool reveals the extent of gene-restructuring events in noncoding sequences. An interactive web portal developed by scientists at KAUST offers a platform for cancer researchers to ...