肿瘤微环境中的代谢物与细胞互作深刻影响Tpex细胞干性。乳酸、琥珀酸等代谢物可通过表观遗传机制上调TCF-1，维持干性状态；高钾、酸性环境及树突状细胞、CD4⁺ ...

在全球范围内，心血管疾病是导致人类死亡的首要原因，其中心肌梗死是最常见且最致命的类型之一。心肌梗死会引起大量心肌细胞不可逆死亡，伴随急性炎症反应和成纤维细胞活化，最终形成瘢痕组织，导致心室重构和心功能衰竭。与成年心脏再生能力缺乏不同，出生后短时间内的 ...

该研究鉴定出幼年哺乳动物心脏再生过程中具有核心调控作用的损伤诱导型 Clusterin⁺（Clu⁺）心肌细胞亚群，并揭示其通过重编程巨噬细胞、协调炎症消退与再生信号传递，驱动心肌修复的分子机制，这一发现为心梗后心脏再生提供了全新理论与技术路径。

Leuven, 11 March 2025 – Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center ...

Transplanting human gastric organoids engineered to release insulin in diabetic mice reduced hyperglycemia, offering a ...

Engineered human stomach organoids, transplanted into mice, produced insulin-secreting cells, offering a potential new ...

In recent years, we have come to appreciate that loss or dysfunction of insulin-producing islet beta cells underlies virtually all major forms of diabetes mellitus. In type 1 diabetes, beta cells ...

Researchers have discovered that targeting PD-L1 recycling in myeloid cells enhances T-cell activation and boosts the effects ...

Cancer immunotherapy has advanced the field of medicine and cancer care. Specifically, immunotherapy refers to the targeted treatment of the immune system. Over the last few decades, immunotherapy has ...

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...