The Pap test is currently central to the detection of cervical cancer precursors. Conventional smears, whose utilisation started in the early 1950s, have been progressively replaced by liquid-based ...

New cancer therapies are frequently evaluated in multiple disease indications. We evaluated whether the probability of achieving US Food and Drug Administration (FDA) approval for a new cancer therapy ...

When designing programs or software for the implementation of Monte Carlo (MC) hypothesis tests, we can save computation time by using sequential stopping boundaries. Such boundaries imply stopping ...

In a previous paper [3], the authors presented large sample optimum accelerated test plans to estimate the survival probability at a design stress assuming a linear logistic model, i. e. a linear ...

We identified a cohort of anticancer drugs with a first registered efficacy trial from 2007 to 2011 on ClinicalTrials.gov. We downloaded all clinical trials for each included drug from the initiation ...

The aim of validating default probabilities is to analyze whether these are not too low. For small sample sizes, however, there are not enough observations available to detect excessively low default ...