Tuberculosis is still one of the deadliest infectious diseases, causing over one million deaths each year worldwide. Additionally, about one-fourth of the world's population carries Mycobacterium ...

Tuberculosis is a serious health threat, and the efficacy of the BCG vaccine against tuberculosis diminishes in adulthood, making booster vaccines a realistic option. Mycobacterial DNA-binding protein ...

Post-translational modifications (PTMs) play a key role in dynamic cellular processes, regulating gene expression, protein activity, localization, and degradation, as well as protein interaction.

The focus of vertebrate studies has mainly been on canonical phosphorylation, but research indicates that phosphorylation of other non-canonical amino acids also regulates integral aspects of cell ...

Chief among these is accurately and reproducibly mimicking natural post-translational modifications. Identifying and characterizing such modifications impact half-life, quality, cost, and potential ...

The amino acid side chains of proteins undergo various post-translational modifications (PTMs) which significantly impact protein function and mediate complex cellular events. Measuring the dynamics, ...

Tsukuba, Japan—Proteins are subject to post-translational chemical modifications that result in functional diversity. Methylation is one such modification that is generally believed to occur on lysine ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

Respiratory infections, pink eye, or an upset stomach may seem like unrelated, mild inconveniences, but all of these ailments share one root cause: adenovirus infection. Many of us will encounter some ...

image: An engineered protein nanopore directed a water flux strong enough to capture, unfold and translocate proteins exceeding 1200 amino acids in length. Modulation of electrical current during ...