ncRNA通过多层面驱动耐药的机制，为破局抗HER2治疗困境提供了新视角。人类表皮生长因子受体2（HER2）是乳腺癌、胃癌等多种恶性肿瘤中至关重要的驱动基因和生物标志物。它的过度表达或扩增，与肿瘤的侵袭性增强和不良预后密切相关。曲妥珠单抗作为首个针对 ...

Over the past decade, several tumor-based predictors of cetuximab efficacy have been identified, yet most function as ...

When researchers look for potential cancer therapy targets, they typically go after protein-coding genes that participate in ...

该文重点解析了三类主要ncRNA在心血管衰老中的调控作用。文章总结这些ncRNA通过调节心血管细胞衰老、代谢重编程、炎症反应、纤维化、自噬和凋亡等关键生物学过程，深度参与心血管衰老进程。为更清晰地理解ncRNA的复杂功能，作者创新性地将其分为四类：抗 ...

The oldest RNA ever reported until now came from a 14,300-year-old “wolf” puppy frozen in permafrost. But when Mármol-Sánchez ...

Sunlight is vital for human health as it helps the body produce essential nutrients, such as vitamin D. However, too much sun ...

Researchers from Stockholm University extracted the RNA sequences from a juvenile mammoth (named Yuka) that died almost ...

最近，Nat Commun上的一项研究，Paternal SARS-CoV-2 infection impacts sperm small noncoding RNAs and increases anxiety in offspring in a sex-dependent ...

A new University of Chicago study explores how prolonged exposure to ultraviolet (UV) radiation can trigger inflammation in skin cells through degradation of a key protein called YTHDF2. This protein ...

circRNA, circular RNA; dsRNA, double-stranded RNA; lncRNA, long non-coding RNA; mRNA, messenger RNA; miRNA, microRNA; ncRNA, non-coding RNA; pre-miRNA, precursor miRNA; pri-miRNA, primary miRNA; RISC, ...