Picking the right items in Megabonk can completely shift how your run plays out. Some items make your character unstoppable, no matter the build, while others only work in specific setups or moments.

October 21, 2025: Revised the Megabonk tier list to reflect version 1.0.17, which has seen tweaks to low-tier characters like Birdo, Bush, and Robinette. Also fixed the incorrect placement of Joe's ...