According to the 'classical' view, histone modifications are established in an identical fashion on both copies of each of the four core histones, resulting in 'symmetrically' modified nucleosomes.

Until recently, proteins called "histones" have been the Rodney Dangerfields ("I don't get no respect!") of the biochemical world. Histones bind to DNA and wrap the genetic material into "beads on a ...

Occasionally, two research disciplines converge at precisely the right moment and propel each other forward. Such is the case with a screen for growth regulators in acute myeloid leukemia and a small ...

What is the histone code? Different chemical marks, such as acetylation, methylation, or phosphorylation, are made to numerous residues on the N-terminal tails of histone proteins. Some posit that ...

Covalent modification of DNA and histone molecules, the core components of chromatin, provides a heritable mechanism for regulating gene expression 1,2. These histone marks function cooperatively to ...

Scientists have created a new research tool, based on the fruit fly, to help crack the histone code. This research tool can be used to better understand the function of histone proteins, which play ...

University of North Carolina scientists have created a new research tool, based on the fruit fly, to help crack the histone code. This research tool can be used to better understand the function of ...

Test system on fruit flies should provide the key to histone function. The genetic inherited material DNA was long viewed as the sole bearer of hereditary information. The function of its packaging ...