The authors investigated the epigenetic mechanisms regulating the differentiation of circulating monocytes that infiltrate the CNS and adopt microglia-like characteristics. The work is useful to the ...

Single cell gene expression studies often rely on single-cell RNA sequencing (scRNA-seq) alone. While scRNA-seq reveals which genes are turned on, it does not capture protein expression or changes to ...

A newly developed mouse model enables real-time visualization of RNA Polymerase II (RNAP2) during DNA transcription, as ...

2025 年 10 月 6 日，诺贝尔生理学或医学奖授予美国科学家玛丽 · 布伦科（Mary E. Brunkow）、弗雷德 · 拉姆斯德尔（Fred Ramsdell）和日本科学家坂口志文（Shimon ...

Rapid precision run-on sequencing (rPRO-seq) may help doctors understand disease states and treatment response in real time. Researchers at Sylvester Comprehensive Cancer Center (FL, USA) have ...

The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins -- yet it exists in large quantities. A research team has ...

Enhancers play a crucial role in directing gene expression programs essential for cellular differentiation and development. Recent advancements in 3D genome ...

This article explores how epigenetic mechanisms control gene expression, how their disruption drives cancer and how targeting ...

Understanding how to control stem cell differentiation has been a pivotal pursuit in biomedical research. Recent findings highlight the significant role of RNA condensates, particularly P-bodies, in ...

Acetylation of lysine residues in the tail domain of histone H3 is well characterized, but lysine residues in the histone globular domain are also acetylated. Histone modifications in globular domain ...