Metabolic bone disease describes a diverse group of disorders of bone metabolism, most commonly caused by abnormalities of minerals (such as calcium or phosphorous) or vitamin D. Cystic fibrosis is ...

本综述系统阐述了p38 MAPK信号预调控对dECM扩增人滑膜干细胞（SDSC）命运决定的特异性调控作用。研究发现p38抑制剂SB203580通过上调Wnt11增强软骨分化，而激活剂anisomycin通过Wnt5a通路促进软骨肥大化和成骨分化，为炎症环境下干细胞定向分化调控提供了新策略。