CRISPR-Cas9 has been widely adapted for use in transcriptional modulation and epigenetic engineering with deactivated Cas9 (dCas9) systems to enable CRISPR interference (CRISPRi) and CRISPR activation ...

Beverly A. Rothermel is in the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Read the paper: Myocardial reprogramming by HMGN1 underlies ...

Approach that uses cell’s own strategy of liquid-liquid phase separation protects synthetic modifications from being washed away by the tide of cell growth.

The immune system works to identify and target invading pathogens. Specifically, our bodies work to get rid of any harmful infections by employing a two-part immune response. The first wave of ...

Although heart cells and skin cells contain identical instructions for creating proteins encoded in their DNA, they're able ...

Martin Kear does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their ...

Gene Simmons crashed his vehicle into a parked car in Malibu and seemingly came close to going right over a cliff and into the ocean, according to footage of the incident. A video shared by TMZ showed ...

Most current approaches rely on adding nuclear localization signal (NLS) motifs to the ends of Cas9 to facilitate nuclear entry. However, this method is inefficient, and much of the Cas9 that is ...

SLC35G3-mediated UDP-GlcNAc transport is essential for proper sperm glycoprotein formation and male fertility.