In modern functional genomics, understanding how specific genes control cellular behavior requires both targeted intervention and high-resolution analysis. That’s where Perturb-Seq comes in—a method ...

Artificial intelligence can predict on- and off-target activity of CRISPR tools that target RNA instead of DNA, according to new research published in Nature Biotechnology. The study by researchers at ...

The study combines a deep learning model with CRISPR screens to control the expression of human genes in different ways -- such as flicking a light switch to shut them off completely or by using a ...

CRISPR-Cas systems are adaptive immune systems found in prokaryotes that defend against invading nucleic acids through CRISPR RNA-guided cleavage. Type V CRISPR-Cas (Cas12) systems, in particular, ...

Bacteria-attacking viruses, known as bacteriophages, use small RNAs to disarm the CRISPR-Cas immune systems of bacteria. This discovery has now been documented by researchers at the University of ...

CRISPR-Cas9 enables researchers to make precise and targeted edits in the genome to determine gene function. For this, scientists use guide RNAs, which are short stretches of RNA sequences that lead ...

Multiple CRISPR technologies are being used to specifically alter or silence genes and inhibit protein production. One of these tools is CRISPRi (CRISPR interference) which blocks genes and gene ...

A CRISPR system detects rare cancer mutations in blood with single-nucleotide precision, outperforming ddPCR through engineered RNA guides and isothermal amplification. (Nanowerk Spotlight) Hidden ...