本文创新性地将Y型DNA纳米结构与CRISPR-Cas12a系统协同整合，开发了一种新型荧光适体传感器。该传感器以AFB1特异性适体（Apt）为分子开关，通过链置换反应（SDR）生成富含激活序列的Y型DNA组装体，精确激活Cas12a的反式切割（trans-cleavage）活性，并利用磁性 beads ...

本推荐语：本研究创新性地构建了以Ru(phen)32+/AuNCs为供受体对的电化学发光共振能量转移（ECL-RET）体系，结合CRISPR-Cas12a系统的 ...

Like humans, bacteria and archaea can be attacked by viruses. These microorganisms have developed their own immune defense strategies against their pathogens. Bacterial defenses, such as CRISPR-Cas ...

Earlier this year, researchers at CHOP and Penn created a first-of-its-kind drug customized to a unique genetic mutation to save an infant named Baby KJ from dying of a rare liver disorder. KJ Muldoon ...

This article was written for our sponsor, Innovation Road Trip. Eradication of certain diseases, increasing crop sizes, reducing pest populations — the current and future applications of CRISPR have ...

Owen T. Tuck, a graduate student in Jennifer Doudna’s lab at the University of California. Owen T. Tuck, a graduate student in Jennifer Doudna’s lab at the University of California, Berkeley, thinks ...

CRISPR was one of the most influential breakthroughs of the last decade, but it's still imperfect. While the gene editing tool is already helping people with genetic ailments, scientists are also ...

A powerful form of DNA-editing machinery discovered in bacteria might allow us to make much bigger changes to genomes than is currently possible with CRISPR-based techniques. However, it isn’t yet ...