Clinical recommendations for predictive risk assessment aim to reduce the incidence of severe hyperbilirubinemia and bilirubin encephalopathies while minimizing the risks of unintended harm such as ...

More than 15 years in the making, the revised AAP Clinical Practice Guideline Revision: Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation was released in 2022. A key ...

Bilirubin, the primary breakdown product of hemoproteins, particularly hemoglobin, plays a key role in the diagnosis, prognosis, and monitoring of liver diseases. In acute liver diseases, such as ...

The yellow bile pigment bilirubin has a bad reputation. The normal end-product of hemoglobin breakdown, in excess it causes jaundice, lethargy, seizures, and death. Yet, people with only slightly ...

The strategy includes examination of infant eye color, stool color, and prior laboratory results to assess whether drawing a direct or conjugated bilirubin level is warranted. HealthDay News — In a ...

This is a preview. Log in through your library . Abstract The relationship between circulating total bilirubin and incident non-alcoholic fatty liver disease (NAFLD) is uncertain. We aimed to assess ...

Gene therapy for Crigler-Najjar syndrome appeared promising in patients treated at a higher dose, a phase I/II trial showed. A single infusion of GNT0003 -- an adeno-associated virus serotype 8 vector ...

Effective treatments for patients with primary biliary cholangitis are limited. Seladelpar, a peroxisome proliferator–activated receptor delta agonist, has potential benefits. In this phase 3, ...

Primary biliary cholangitis is a rare, chronic cholestatic liver disease characterized by the destruction of interlobular bile ducts, leading to cholestasis and liver fibrosis. Whether elafibranor, an ...