The SARS-CoV-2 pandemic greatly accelerated the development of messenger RNA technology by demonstrating the safety, effectiveness and scalability of mRNA-based vaccines 1. Writing in Nature, Zhang et ...

We tested how one of the most common modifications present in mRNA coding regions, pseudouridine (Ψ), impacts protein synthesis using a fully reconstituted bacterial translation system and human cells ...

In cap-dependent translation initiation, the open reading frame (ORF) of mRNA is established by the placement of the AUG start codon and initiator tRNA in the ribosomal peptidyl (P) site. Internal ...

In Part I of this series providing a summary of the mRNA IP and competitive landscape through one year of the COVID-19 pandemic, we focused on market players BioNTech, Moderna and CureVac; in Part II, ...

In a recent study published in Cell Reports, researchers evaluate the response of pre-existing immunity to booster doses of messenger ribonucleic acid (mRNA) coronavirus disease 2019 (COVID-19) ...

Producing a successful seasonal flu vaccine requires a bit of fortune-telling. Each vaccine can target only up to four different flu viruses, of which there are many. If scientists’ predictions about ...