The regulation of neuronal excitability and the maintenance of an appropriate balance between excitation and inhibition are central to brain function. Inhibitory synaptic transmission, predominantly ...

Physiological functioning and homeostasis of the brain rely on finely tuned synaptic transmission, which involves nanoscale alignment between presynaptic neurotransmitter-release machinery and ...

How do we think, feel, remember, or move? These processes involve synaptic transmission, in which chemical signals are transmitted between nerve cells using molecular containers called vesicles. Now, ...

(1) A nerve impulse arrives. (2) This causes calcium ion channels to open, resulting in an influx of calcium ions in the terminal. (3) This causes synaptic vesicles to fuse with the terminal membrane, ...

The synaptotagmin protein family has been studied by neuroscientists for decades. However, most isoforms lack well-defined functions. Now, researchers have identified a crucial, presynaptic role for ...

Two distinct pools of synaptic vesicles appear to be involved in the spontaneous release of neurotransmitters and in neurotransmission triggered by a stimulus, according to Ege T. Kavalali and ...

Two distinct pools of synaptic vesicles appear to be involved in the spontaneous release of neurotransmitters and in neurotransmission triggered by a stimulus, researchers report in Neuron this week.