本研究针对单纯疱疹病毒2型(HSV-2)感染机制不明的问题，揭示了宿主蛋白UXT-V2通过招募E3泛素连接酶TRIM21促进HSV-2糖蛋白B(gB)的K48连接泛素化降解，从而抑制病毒复制的新机制。研究发现UXT-V2通过蛋白酶体途径特异性降解gB，而HSV-2则通过复制依赖性方式降低UXT-V2 ...

据“百克生物”微信公众号，9月9日，百克生物在北京市积水潭医院召开“HSV-2 mRNA疫苗在18周岁至55周岁不同血清学感染受试者中安全性、耐受性与免疫原性的I期剂量递增试验”启动会。 启动会围绕生殖器疱疹疾病及疫苗研发背景、GCP规范、临床试验方案、研究 ...

Herpes simplex virus is a common infection that typically appears in and around the mouth (oral herpes) or the genitals (genital herpes). Ulcers may cause pain but usually resolve within a few days or ...

Assembly Biosciences Inc (($ASMB)) announced an update on their ongoing clinical study. Study Overview: Assembly Biosciences Inc. is conducting a ...