Remodelling of RNA structures by proteins such as the DEAD-box (DDX) RNA helicases regulates gene expression at various stages. The budding yeast helicase Dhh1 and its human counterpart DDX6 are known ...

Identifying functional effects of noncoding variants is a major challenge in human genetics. To predict the noncoding-variant effects de novo from sequence, we ...

Premise of research. The transition from herbaceous annual to woody perennial has occurred numerous times during angiosperm evolution, but the suite of genetic changes that accompanies this life ...

Henry M. Kronenberg, Barbara E. McDevitt, Joseph A. Majzoub, Jeremy Nathans, Phillip A. Sharp, John T. Potts and Alexander Rich Proceedings of the National Academy of Sciences of the United States of ...

Superimposed on the genetic sequences coding for amino acids is a second genetic code. This second genetic code, which makes use of dual-use codons, or duons, specifies how genes are controlled. The ...

AMSTERDAM--(BUSINESS WIRE)--Annogen, the Amsterdam based biotech company behind the SuRE™ technology for the functional annotation of the non-coding part of the genome, today announced it has begun a ...

T-cell inflamed phenotype gene expression signatures to predict clinical benefit from pembrolizumab across multiple tumor types. This is an ASCO Meeting Abstract from the 2016 ASCO Annual Meeting I.

A DNA sequence code critical to our understanding of how human genes are turned on and off has just been unlocked by a team of scientists. Molecular biologists refer to this code as the “human ...

Using STING-seq, short for systematic targeting and inhibition of noncoding GWAS loci with single cell sequencing, Sanjana and his team identified promising sequence variants linked to various ...

RNA vaccines are a new class of vaccines that are composed of an mRNA sequence coding for a pathogen-specific protein (antigen). Once expressed in the body, the target antigen is recognized by the ...