编辑丨王多鱼排版丨水成文RNA 修饰是“表观转录组学”的核心研究对象，广泛参与 RNA 稳定性、剪接和翻译等生物学过程，精准调控 RNA 命运。牛津纳米孔技术（ONT）推出了直接 RNA 测序（DRS）方案，无需扩增直接对 RNA ...

团队进一步利用合成的 MIReccDNA 进行功能验证，发现这些环状 DNA 可在 肿瘤细胞 中被稳定转录，并显著促进肾 癌细胞 增殖与恶性表型。这一发现首次提供了直接证据，表明小型 eccDNA 并非被动产物，而是可以携带特定 miRNA ...

长期以来，科学家们对微生物在人类癌症中的作用抱有浓厚兴趣。然而，大多数癌症微生物组的研究焦点都集中在微生物丰度较高的器官，如口腔、胃和结肠。相比之下，对于肺部这类历史上曾被认为是“无菌”器官的微生物组研究则相对滞后。尽管基于痰液或支气管肺泡灌洗液 ...

RNA sequence design and inverse folding constitute pivotal areas in computational biology, aiming to identify nucleotide sequences that adopt predetermined structural conformations. The inverse ...

专注于AS转录本，该研究严格的筛选管道确定了34种新抗原，优先考虑强免疫原性，以开发有效的疫苗。体内概念验证实验证明了编码这些新抗原的mRNA疫苗的有效性，导致肿瘤显著消退，并增强肿瘤内新抗原反应性T细胞的浸润。该研究还通过提出使用TAP独立的AS衍 ...

This article explores how challenges such as sequence optimization, immune activation and off-target effects are being ...

Spatial RNA medicine combines transcriptomics and RNA therapeutics, mapping gene expression in tissues to enhance precision ...

UC Vice President for Research Patrick Limbach is a key figure in the National Academies’ massive undertaking to sequence RNA in the next 15 years. A chemist who leads the University of Cincinnati’s ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 4 (January 25, 2022), pp. 1-11 (11 pages) RNA is a ubiquitous biomolecule that can serve as both catalyst ...

Scientists have sequenced RNA from a nearly 40,000-year-old woolly mammoth leg, the oldest ancient RNA ever recovered. These ...

Cell free RNA diagnostics market is projected to reach US$ 204.5 Mn by 2035, expanding at a CAGR of 14.5% from 2025 to 2035 ...