In Alzheimer's Disease and other neurodegenerative dementias, proteins that normally play a role in healthy brain tissue turn bad, clumping together to form insoluble plaques and tangles as neurons ...

Researchers have discovered how unstructured segments of surface proteins regulate the biological function of a cell. Their study, published in Nature Communications, sheds new light on the interplay ...

A major scientific advance in protein modeling developed by Microsoft Research AI for Science, has been published in Science. The study introduces BioEmu, a generative deep learning system that ...

HSP90 chaperone undergoes dynamic cycling process: HSP90 transits between open and closed states to promote maturation of polypeptide clients into functional proteins with the help of ATP and a ...

Researchers are helping to reveal the molecular secrets of macular degeneration, which causes almost 90% of all age-related vision loss. Research led by Sanford Burnham Prebys professor Francesca ...

Johns Hopkins engineers have helped develop and characterize an artificial protein that triggers the same response in the human body as its natural counterpart—a breakthrough that not only has the ...

Researchers from The University of Osaka find that CFAP91 and EFCAB5 proteins are crucial for sperm motility, and that loss of function of either of these proteins reduces male fertility in mice Osaka ...

It has long been thought that protein function and stability are highly sensitive to changes in the composition of the internal structures, or protein cores. However, a large-scale experiment probing ...

Myristoylation was discovered about three decades ago, and research in this field of life sciences has led to a deeper understanding of its significance in several processes. This process plays a key ...