Protein AMPylation represents a specialised post‐translational modification (PTM) in which an adenosine monophosphate (AMP) moiety is covalently attached to specific amino acid residues on target ...

An epigenetic sensor uses a 21st amino acid to illuminate protein dynamics in real time to observe changes within cells.

DnaK/DnaJ or Trigger factor and find that chaperone dependence during primary biogenesis in vivo does not track with ...

Post-translational modifications (PTMs) are essential biochemical changes that proteins undergo after synthesis, playing a crucial role in regulating ...

A comprehensive review in Current Molecular Pharmacology reveals how TCF/LEF proteins control Wnt signaling through dynamic enhanceosome assembly, post-translational modifications, and isoform ...

The complexity and heterogeneity of protein therapeutics present significant challenges in biologics discovery, as ...

Proteomics—a term first coined in the mid-1990s—refers to the study of the complete set of proteins expressed in a cell, tissue, or organism. In contrast to genomics and transcriptomics, proteomics is ...

Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly.

Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric ...

Research in the field of ubiquitination has unveiled it as a fundamental post-translational modification mechanism that meticulously directs protein fate ...

Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and disease ...