This study provides valuable insights into the role of the NF-kB and IKK signaling pathways in γδ T cell development and survival, using robust genetic mouse models. While the research is ...

Nuclear speckles are non–membrane-bound organelles known as storage sites for messenger RNA (mRNA) processing and splicing factors. More recently, nuclear speckles have also been implicated in ...

More than two decades of effort went into a project that has now revealed the structure of a crucial signaling molecule, opening the door to new and better drugs for some cancers. For more than 20 ...

Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems. These ...

We played a major role in revealing the biochemical steps of the RAS-RAF-MAP kinase pathway. We identified one of the major ...

The protein kinase CK2 is involved in a wide range of biological processes and cellular functions, including inflammatory responses and pathologies associated with inflammation. Also, its aberrant ...

This is a preview. Log in through your library . Abstract Drought stress seriously limits crop productivity. Although studies have been carried out, it is still largely unknown how plants respond to ...

Drug development of novel agents in NSCLC continues to evolve based on disease subtype identification and new pharmaceutical approaches. Molecular alterations in NSCLC that drive cancer growth have ...

Inhibition of the COQ8 protein could be beneficial in the treatment of diseases such as cancer. COQ8 is needed for the biosynthesis of coenzyme Q, also known as ubiquinone. A new collaborative study ...

Kygevvi (doxecitine and doxribtimine) earned FDA approval as the first treatment for thymidine kinase 2 deficiency, supported by data from a Phase II trial and multiple retrospective studies showing ...