In epidemiologic studies and disease prevention trials, interest often involves estimation of the relationship between some disease endpoints and individual exposure. In some studies, due to the ...

For a desired power of detecting the association between a disease and several potential risk factors in case-control studies, Yang (1978, Biometrika 65, 635-640) and Halperin (1980, Biometrika 67, ...

A genome-wide association study ascertains through genome, potential genetic associations between genetic polymorphism and observable traits or disease. 1, 2 Recent advances in DNA technology made it ...

Implementation of the Time-to-Event Continuous Reassessment Method Design in a Phase I Platform Trial Testing Novel Radiotherapy-Drug Combinations—CONCORDE BayeSize applies the concept of effect size ...

Cheung and colleagues warned that underpowered studies that committed a type II error will discourage clinicians from using effective treatment.1 I agreed with this ...

Back in the day, we learned in statistics that you need a sample size of at least 2% of the size of population to make statistically significant conclusions about the behavior of the population. In ...

calculate confidence intervals for the mean using the t or z distributions (depending upon the sample size) complete formal hypothesis tests about whether a sample mean is different from a specific ...