Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...

Despite the diversity inherent to cancer, they all share a common theme: many things tend to go wrong. This can make it difficult to understand which factors are driving the cancer and which ones are ...

The incidence of Human Papillomavirus (HPV)-associated oropharyngeal cancers — tumors of the back of the mouth and throat — is rising. If caught early, most of these cancers have a high survival rate, ...

This is a preview. Log in through your library . Abstract Extrachromosomal circular DNA (eccDNA) originates from linear chromosomal DNA in various human tissues under physiological and disease ...

Cancer therapies can eliminate specific tumors based on their genetic content. However, some cancer cells survive. How do they do it? Part of the answer lies in extrachromosomal DNA (ecDNA), an ace up ...

SAN DIEGO--(BUSINESS WIRE)--Boundless Bio, a clinical stage, next-generation precision oncology company interrogating extrachromosomal DNA (ecDNA) biology to deliver transformative therapies to ...

Lukas Chavez uses multiomic techniques to study how extrachromosomal DNA (ecDNA) contributes to tumor heterogeneity and gene expression changes in medulloblastoma. In the 1960s, researchers in England ...

A study of newly created databases of medulloblastoma has found that patients with tumors containing circular extrachromosomal DNA - loops of DNA found outside of regular chromosomes - are twice as ...