Cells are continuously faced with endogenous stress (for example, during replication) and exogenous stress (for example, during exposure to ultraviolet radiation) that can ultimately lead to DNA ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

The semiconservative mode of DNA replication was originally documented through the classic density labeling experiments of Matthew Meselson and Franklin W. Stahl, as communicated to PNAS by Max ...

This is a preview. Log in through your library . Abstract In eucaryotic cells chromosomes must be fully replicated and repaired before mitosis begins. Genetic studies indicate that this dependence of ...

A new study published in Nature Structural & Molecular Biology reveals how the fundamental enzyme called DNA polymerase delta operates during DNA replication, making a copy of the genetic code that ...

Scientists reported a novel molecular mechanism for the regulation of PCNA cycling during DNA replication. They proved that ATAD5-RLC opens PCNA ring to be removed from DNA as a bona-fide PCNA ...

Life depends on double-stranded DNA unwinding and separating into single strands that can be copied for cell division. Scientists have determined at atomic resolution the structure of machinery that ...

Nanoscale “robots” made of DNA that rapidly self-replicate could be harnessed to manufacture drugs or other chemicals inside the body, say researchers. Tiny machines made of DNA origami may make ...