In a series of experiments using human cancer cell lines, scientists at Johns Hopkins Medicine say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, ...

New research from a team of genome scientists and DNA damage response experts breaks new ground in understanding the function of a protein currently limited in clinical trials for cancer treatments.

Malignant gliomas, the deadliest of brain neoplasms, show rampant genetic instability and resistance to genotoxic therapies, implicating potentially aberrant DNA damage response (DDR) in glioma ...

Scientists have long known that human genes spring into action through instructions delivered by the precise order of our DNA, directed by the four different types of individual links, or "bases," ...

CD20-immunotargeting of malignant melanoma. Background: Inability to repair ultraviolet light (UV)-induced DNA damage causes skin cancer. Chloroquine has been shown to activate the DNA damage response ...

A key challenge facing doctors as they treat patients suffering from cancer or other diseases resulting from genetic mutations is that the drugs at their disposal often don't discriminate between ...

Researchers at The Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence to design thousands of new DNA switches that can precisely ...

Blacksburg, Va., March 27, 2007 – Chemists and biologists at Virginia Tech continuing to design light-activated molecular systems to attack cancer cells have introduced a DNA targeting component. They ...