A figure from the paper illustates a key finding of "compromised compartmentalization": chromatin that was locking genes down in health became more open in Alzheimer's, while chromatin that was open ...

A newly developed mouse model enables real-time visualization of RNA Polymerase II (RNAP2) during DNA transcription, as ...

Cyclone is a portable gene-switch system that uses acyclovir to reversibly control gene expression with minimal toxicity.

Origin-recognition complex, or ORC, plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports. This is the first detailed study ...

The research field of 'cellular IRESes' lay dormant for decades, as there was no uniform standard of reliable methods for the clear characterization of these starting points for the ribosome-mediated ...

In the Living Brain Project, researchers leveraged deep brain stimulation surgeries to compare the brains of the living to ...

The 55th Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research has been awarded to professor Steven ...

Early-stage lung adenocarcinoma alters DNA methylation, mRNA transcription, and protein expression in adjacent tissues, exhibiting either steep changes at the tumor boundaries or shallow changes ...

Scientists at St. Jude Children's Research Hospital and Northwestern University identified a previously unknown treatment ...

For decades, synthetic biologists have been developing gene circuits that can be transferred into cells for applications such as reprogramming a stem cell into a neuron or generating a protein that ...