本文报道了利用DNA-free CRISPR/Cas9技术对淀粉马铃薯品种"Kuras"中甾体糖生物碱（SGA）生物合成通路的关键基因进行定向编辑，成功获得SGA含量显著降低的突变体。研究靶向胆固醇合成前（SMO1-L、DWF1-L、DWF7-L）及合成后（16DOX、CYP88B1、TAMiso2）的6个关键基因，通过 ...

这篇综述系统阐述了CRISPR系统与表观遗传修饰之间的双向互作，创新性地提出了“CRISPR-表观遗传调控回路”模型。文章详述了表观遗传景观（如DNA甲基化、组蛋白修饰）如何影响CRISPR（Clustered Regularly Interspaced Short Palindromic Repeats）编辑效率，同时揭示了CRISPR ...

Explore CRISPR technology explained, gene editing science, DNA modification, and genetic engineering ethics—discover how ...

CRISPR has the power to correct genetic mutations, but current delivery methods are either unsafe or inefficient, keeping the technology from reaching its full medical potential. With the power to ...

We performed both homology-based and GUIDE-seq nomination of candidate off-target sites, which resulted in the testing of 5002 sites from four healthy donors (not shown). We then nominated additional ...

Traditional breeding and genetic modification methods have struggled to keep pace with the rapid evolution of plant viruses. CRISPR/Cas systems, originally derived from bacterial immune responses, ...

Researchers are further improving CRISPR's versatility to engineer new grasses and yeasts for biochemical production. CRISPR/Cas systems have undergone tremendous advancement in the past decade. These ...

The gene-editing technique known as CRISPR is promising to revolutionize medicine. Some researchers are trying to help make it available for people with very rare genetic disorders. A gene-editing ...

Thinking about CRISPR Therapeutics and wondering if now is your chance to scoop up value, or if the stock is already priced in with the excitement? Let's break down what the numbers and news say about ...

WEST LAFAYETTE, Ind. — More than a decade ago, scientists harnessed a bacterial molecular machine that identifies and cuts specific sections of DNA, revolutionizing the ability to edit genes and ...