这篇综述聚焦慢性髓性白血病（CML），详细阐述了 BCR::ABL 激酶相关靶向治疗。从 CML 发病机制、BCR::ABL 蛋白异构体，到现有酪氨酸激酶抑制剂（TKIs）治疗及耐药原因，还介绍了新兴疗法，为 CML 治疗研究提供了全面参考。 慢性髓性白血病（CML）概述 慢性髓性 ...

为解决慢性髓性白血病（CML）患者白血病干细胞（CML LSCs）对酪氨酸激酶抑制剂（TKI）不敏感、难以实现无治疗缓解（TFR）的问题，研究人员开展 TM5614 联合 TKI 治疗 CML 的研究。结果显示联合疗法安全有效，有望实现 TFR，意义重大。 在血液疾病的领域中，慢性髓 ...

Imatinib is a highly effective therapy for chronic phase-chronic myeloid leukaemia (CP-CML) patients; however, responses to frontline imatinib are variable. The human organic cation transporter 1 ...

Chronic myeloid leukemia (CML) is a type of cancer that affects blood-forming tissues. With appropriate treatment, it is possible for people with CML to experience remission. In the 1970s, the 5-year ...

Phase II Multicenter, Randomized, Double-Blind Controlled Study of Efficacy and Safety of Umbilical Cord–Derived Mesenchymal Stromal Cells in the Prophylaxis of Chronic Graft-Versus-Host Disease After ...

Medications for CML directly destroy cancer cells or help the body’s immune system attack cancer cells to prevent them from growing. Medications may not cure CML, so people may need to continue taking ...

Chronic myelogenous leukemia (CML) is a cancer that affects your blood cells and bone marrow -- the soft part inside your bones where blood cells are made. You may also hear your doctor call it ...